Cytosolic and nuclear calcium signaling in plants

 
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Research director: Christian Mazars, CNRS Researcher, mazars@scsv.ups-tlse.fr

 

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Thesis


Plants are continuously subject to a myriad of external stimuli which in turn contribute to their growth and development. To successfully adapt to a particular environment, plants have to perceive these stimuli and to convert them into a biological language which leads to their adaptive physiological responses. An intriguing aspect of these signalling processes is the fact that while the number of potential signals is very important, the intracellular mediators that allow their conversion into biological responses is very limited.


Our research projects aim (i) at deciphering the biological mechanisms involved in the decoding of the informations carried by abiotic or biotic signals and (ii) at understanding how the plant response specificity is generated.


For this purpose we are using different biological models which allow us to address the following specific questions related to these projects :


- What is the role of the nuclear compartment in the specificity of the plant responses to external stimuli ?


- What are the molecular mechanisms allowing specific recognition and biological response upon interaction between signals of microbial origin and their putative receptors ?




  Research Topics

> Cell signaling - cytosol-nucleus dialogue and response specificity
> Rhizobium-legume symbiosis: molecular signalling upstream to gene expression

  Keywords

cytosolic calcium, nuclear calcium, calcium signature, sphingolipids, second messengers, cell signaling, regulation networks, cross-talk, gravity, phosphorylation, phosphoproteome, 14-3-3, protein-protein interaction, aequorine, BY2 cells.